Schedule

Following is a tentative course schedule, which is subject to change as the course progresses.


Weekly activities

Lecture
Mondays and Wednesdays, 1-2:30 pm, 100 Broad
TA OHs
Sundays, 1-2:30 pm, 106 Spalding
Fridays, 3:30-5 pm, 106 Spalding
JB's OHs
Thursdays, 2:30-4:00 pm, 100 Broad


Lecture schedule

Lecture 1
(M 01/04) What is Physical Biology of the Cell?
Reading: PBoC2 Ch. 1, CBBTN "The Path to Biological Numeracy"
Lecture 2
(W 01/06) Cell biology by the numbers / Principles of estimation
Reading: PBoC2 2.1, 2.2., 3.1, 3.2
Lecture 3
(M 01/11) Mathematizing cartoons (accompanying Jupyter notebook)
Lecture 4
(W 01/13) Statistical mechanics of molecular interactions
Reading: PBoC2 Ch. 6
Lecture 5
(W 01/20) Two-state models
Reading: PBoC2 Ch. 7
Lecture 6
(M 01/25) Allostery and the Monod-Wyman-Changeux model
Reading: Marzen, et al., 2013
Lecture 7
(W 01/27) Statistical mechanics of gene expression regulation
Reading: PBoC2 19.1, 19.2, Bintu, et al., 2005
Lecture 8
(M 02/01) Dynamics of gene expression / Genetic switches
Reading: PBoC2 19.3-19.5
Lecture 9
(W 02/03) Genetic switches
Lecture 10
(M 02/08) Mass conservation, random walks, and diffusion
Reading: PBoC2 Ch. 13
Lecture 11
(W 02/10) Introduction to biopolymers / Wormlike chain
Reading: PBoC2 8.1-8.3, 10.1-10.3
Lecture 12
(W 02/17) DNA looping and packaging
Reading: PBoC2 10.4
Lecture 13
(M 02/22) Actin and microtubules: buckling and length control
Reading: PBoC2 10.5, 15.1, 15.3-15.5
Lecture 14
(W 02/24) Lecture canceled
Lecture 14
(M 02/29) Molecular motors: active transport and force generation
Reading: PBoC2 Ch. 16
Lecture 15
(W 03/02) The cell as a material / Viscoelasticity
Reading: Kasza, et al. 2007
Lecture 16
(M 03/07) Compartmentalization by phase separation
Reading: Hyman, Weber, and Jülicher, 2014
Lecture 17
(W 03/09) Course recap