Following is a tentative course schedule, which is subject to change as the course progresses.
Weekly activities
- Lecture
- Mondays and Wednesdays, 1-2:30 pm, 100 Broad
- TA OHs
- Sundays, 1-2:30 pm, 106 Spalding
- Fridays, 3:30-5 pm, 106 Spalding
- JB's OHs
- Thursdays, 2:30-4:00 pm, 100 Broad
Lecture schedule
- Lecture 1
- (M
01/04) What is
Physical Biology of the Cell?
Reading: PBoC2 Ch. 1, CBBTN "The Path to Biological Numeracy" - Lecture 2
- (W 01/06)
Cell biology by the numbers / Principles of estimation
Reading: PBoC2 2.1, 2.2., 3.1, 3.2 - Lecture 3
- (M 01/11) Mathematizing cartoons (accompanying Jupyter notebook)
- Lecture 4
- (W 01/13)
Statistical
mechanics of molecular interactions
Reading: PBoC2 Ch. 6 - Lecture 5
- (W 01/20)
Two-state models
Reading: PBoC2 Ch. 7 - Lecture 6
- (M 01/25)
Allostery and the Monod-Wyman-Changeux model
Reading: Marzen, et al., 2013 - Lecture 7
- (W 01/27) Statistical mechanics of gene
expression regulation
Reading: PBoC2 19.1, 19.2, Bintu, et al., 2005 - Lecture 8
- (M 02/01)
Dynamics of gene expression / Genetic switches
Reading: PBoC2 19.3-19.5 - Lecture 9
- (W 02/03) Genetic switches
- Lecture 10
- (M 02/08)
Mass conservation, random walks, and diffusion
Reading: PBoC2 Ch. 13 - Lecture 11
- (W 02/10)
Introduction to biopolymers / Wormlike chain
Reading: PBoC2 8.1-8.3, 10.1-10.3 - Lecture 12
- (W 02/17)
DNA looping and packaging
Reading: PBoC2 10.4 - Lecture 13
- (M 02/22)
Actin and microtubules: buckling and length control
Reading: PBoC2 10.5, 15.1, 15.3-15.5 Lecture 14- (W 02/24) Lecture canceled
- Lecture 14
- (M 02/29)
Molecular motors: active transport and force generation
Reading: PBoC2 Ch. 16 - Lecture 15
- (W 03/02)
The cell as a material / Viscoelasticity
Reading: Kasza, et al. 2007 - Lecture 16
- (M 03/07)
Compartmentalization by phase separation
Reading: Hyman, Weber, and Jülicher, 2014 - Lecture 17
- (W 03/09) Course recap