Following is a tentative course schedule, which is subject to change as the course progresses.

Weekly activities

Lecture: Mondays and Wednesdays, 2:30-4 pm, 115 Gates-Thomas
TA OHs: Gloria: Mondays, 8-9 pm, 231 SFL; Griffin: Tuesdays, 10-11 am, 231 SFL
JB's OHs: Fridays, 2:30-4 pm, 200 Broad

Lecture schedule

Lecture 1: (W 01/03) What is Physical Biology of the Cell?
Reading: PBoC2 Ch. 1, CBBTN "The Path to Biological Numeracy"
Lecture 2: (M 01/08) Cell biology by the numbers / Principles of estimation
Reading: PBoC2 2.1, 2.2., 3.1, 3.2
Lecture 3: (W 01/10) Mathematizing cartoons (Jupyter notebook)
Lecture 4: (W 01/17) Statistical mechanics of molecular interactions
Reading: PBoC2 Ch. 6
Lecture 5: (M 01/22) Two-state models: Mscl case study
Reading: PBoC2 Ch. 7
Lecture 6: (W 01/24) Allostery and the Monod-Wyman-Changeux model
Reading: Marzen, et al., 2013
Lecture 7: (M 01/29) Statistical mechanics of gene expression regulation
Reading: PBoC2 19.1, 19.2, Bintu, et al., 2005
Lecture 8: (W 01/31) Dynamics of gene expression / Genetic switches
Reading: PBoC2 19.3-19.5
Lecture 9: (M 02/05) Mass conservation, random walks, and diffusion (Jupyter notebook)
Reading: PBoC2 Ch. 13
Lecture 10: (W 02/07) Introduction to biopolymers / Wormlike chain
Reading: PBoC2 8.1-8.3, 10.1-10.3
Lecture 11: (M 02/12) DNA looping and packaging
Reading: PBoC2 10.4
Lecture 12: (W 02/14) Actin and microtubules: buckling and length control
Reading: PBoC2 10.5, 15.1, 15.3-15.5
Lecture 13: (W 02/21) The cytoskeleton, continued
Reading: PBoC2 Ch. 16
Lecture 14: (M 02/26) Molecular motors: active transport and force generation
Reading: PBoC2 Ch. 16
Lecture 15: (M 02/28) The cell as a material / Viscoelasticity
Reading: Kasza, et al. 2007
Lecture 16: (M 03/05) Case study: Spindle positioning
Lecture 17: (M 03/05) Conclusion of case study and course recap
Lecture 18: (auxiliary) Compartmentalization by phase separation and course recap
Reading: Hyman, Weber, and Jülicher, 2014