Following is a tentative course schedule, which is subject to change as the course progresses.

Weekly activities

Lecture: Mondays and Wednesdays, 2:30-4 pm, 200 Broad
TA OHs: Vahe: 7:30-8:30 pm, 231 SFL; Aya: 9-10 am, 231 SFL
JB's OHs: Fridays, 2:30-4 pm, 200 Broad

Lecture schedule

Lecture 1: (M 01/07) What is Physical Biology of the Cell?
Reading: PBoC2 Ch. 1, CBBTN "The Path to Biological Numeracy"
Lecture 2: (W 01/09) Cell biology by the numbers / Principles of estimation
Reading: PBoC2 2.1, 2.2., 3.1, 3.2
Lecture 3: (M 01/14) Mathematizing cartoons (Jupyter notebook)
Lecture 4: (W 01/16) Statistical mechanics of molecular interactions
Reading: PBoC2 Ch. 6
Lecture 5: (W 01/23) Two-state models: Mscl case study
Reading: PBoC2 Ch. 7
Lecture 6: (M 01/28) Allostery and the Monod-Wyman-Changeux model
Reading: Marzen, et al., 2013
Lecture 7: (W 01/30) Statistical mechanics of gene expression regulation
Reading: PBoC2 19.1, 19.2, Bintu, et al., 2005
Lecture 8: (M 02/04) Dynamics of gene expression / Genetic switches
Reading: PBoC2 19.3-19.5
Lecture 9: (W 02/06) Mass conservation, random walks, and diffusion
Reading: PBoC2 Ch. 13
Lecture 10: (M 02/11) Introduction to biopolymers / Wormlike chain
Reading: PBoC2 8.1-8.3, 10.1-10.3
Lecture 11: (W 02/13) DNA looping and packaging
Reading: PBoC2 10.4
Lecture 12: (W 02/20) Actin and microtubules: buckling and length control
Reading: PBoC2 10.5, 15.1, 15.3-15.5
Lecture 13: (M 02/25) More cytoskeletal filaments
Reading: PBoC2 Ch. 16
Lecture 14: (W 02/27) Molecular motors: active transport and force generation
Reading: PBoC2 Ch. 16
Lecture 15: (M 03/04) The cell as a material
Reading: Kasza, et al. 2007
Lecture 16: (W 03/06) Linear viscoelasticity
Lecture 17: (M 03/11) Case study: positioning of the mitotic spindle I
Reading: Grill, et al., 2003; Grill, et al., 2005
Lecture 18: (W 03/13) Case study: positioning of the mitotic spindle II
Reading: Garzon-Coral, et al., 2016